新萄京3522vip-新葡的京集团3522vip-3522vip.com

MENU
Baidu
sogou
Baidu
sogou

3522vip.com

当前位置: 首页» 3522vip.com» Z

张翠军课题组

张翠军课题组

Zhang Cuijun Lab

  课题组长

  张翠军,研究员,博导,农科院青年英才。2010年硕博连读毕业于河北师范大学,2010-2015年在北京生命科学研究所从事转录水平基因沉默分子机制研究,2015-2019年在上海植物逆境中心和美国普渡大学从事异染色质识别蛋白的鉴定和功能研究。长期从事植物生长发育和基因表达的表观遗传学调控研究,在 Nature Communications, The EMBO Journal, Cell Research, Plant Physiology, J Integr Plant Biol等国际一流期刊上发表多篇论文。(本实验室长期招聘多组学生物信息分析、麦类抗病机制方向博士后)

 

  工作经历

  中国农业科学院农业基因组研究所        研究员            2019.10–至今

  中国科学院植物研究所                        研究员             2019.5–2019.9

  普渡大学                                            博士后             2015.8–2019.4

  上海植物逆境生物学研究中心              副研究员          2015.4–2015.8

  北京生命科学研究所                           研究助理          2010.7–2015.4

 

  教育经历

  河北师范大学                            博士&硕士           2005.9–2010.6

  河北师范大学                            本科                    2001.9–2005.6

 

  团队研究方向

  随着全球气候变化和人口增长,我国农业和粮食安全面临着巨大的挑战。课题组将利用基因组学、遗传学、生化与分子生物学等多学科手段解析作物重要农艺性状的分子调控机理。重点研究: 1) 表观遗传调控植物生长发育和环境适应的功能机制;2) 生物信息多组学分析、禾谷镰刀菌致病机理、基因编辑改良麦类抗性等多学科交叉研究。

 

  研究进展

  通过突变体遗传筛选及蛋白质组学方法,先后发现了多个参与DNA甲基化调控和转座子沉默的新基因,完善了RNA介导的DNA甲基化(RdDM)通路,并揭示了转座子沉默的动态调节机制。此外,通过组蛋白多肽亲和纯化及质谱分析,鉴定到植物特有的异染色质修饰特异性识别蛋白,并对其维持DNA甲基化和基因沉默的作用机制进行了深入研究,揭示了染色质修饰和DNA甲基化之间全新的联系。通过免疫共沉淀及质谱技术(IP-MS),发现植物中转座子衍生蛋白能够和HDA6形成蛋白复合体,参与组蛋白去乙酰化及植物开花调控。

 

  PI

  Cuijun Zhang, Principle Investigator, Doctoral Advisor, “Outstanding Young Talent” of Chinese Academy of Agricultural Science (CAAS). He has long been engaged in the study of epigenetic regulation of gene expression and plant development. He has published several papers in Nature Communications, The EMBO Journal, Cell Research, PLoS Genetics, Plant Physiology, J Integr Plant Biol, etc.

 

  Working Experience

  Agricultural Genomics Institute at Shenzhen-CAAS             Professor                                 2019.10–Present

  Institute of Botany, Chinese Academy of Sciences                Professor                                2019.5–2019.9

  Purdue University                                                                   Postdoctoral researcher          2015.8–2019.4

  Shanghai Center for Plant Stress Biology                              associate professor                 2015.4–2015.8

  National Institute of Biological Sciences, Beijing                 Research Associate                 2010.7–2015.4

 

  Education

  Hebei Normal University            Ph.D& Master        2005.9–2010.6

  Hebei Normal University            Bachelor            2001.9–2005.6

 

  Research Interest

  With global climate change and population growth, the agriculture and food security are facing huge challenges. We integrated the use of genomics, genetics, biochemistry and molecular biology to study the molecular mechanisms underlying important agronomic traits in crops. Current research topics: 1) the biological roles of epigenetic regulation in plant development and environmental adaptation; 2) bioinformatics analysis of multi-omics data, molecular mechanisms of host-pathogen interactions, genome editing to improve crop resistance and interdisciplinary research.

 

  Major Achievements

  Through genetic mutant screening and proteomics studies, we identified several new genes which involved in regulating DNA methylation and transposon silencing. Our findings improved the understanding of RNA-directed DNA methylation (RdDM) and revealed the dynamic control of transcriptional silencing (Nature Communications, 2016, 2018; EMBO Journal, 2013, 2018). Transposable elements (TEs) are repetitive sequences that constitute a large part of plant and animal genomes. Although usually considered as selfish or parasitic, TEs are important sources of emerging new genes. We found that a domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation and plant flowering (JIPB, 2021).

 

  Selected Publication

  1.   Xishi Zhou1#, Junna He#, Christos N. Velanis#, Yiwang Zhu, Yuhan He, Kai Tang, Mingku Zhu, Lisa Graser, Erica de Leau, Xingang Wang, Lingrui Zhang, W. Andy Tao, Justin Goodrich*, Jian-Kang Zhu*, Cui-Jun Zhang* (2021) A domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation at genes but not TEs in Arabidopsis. J Integr Plant Biol. doi: 10.1111/jipb.13108

  2.   Zhang CJ#, Du X#, Tang K#, Yang ZL, Pan L, Zhu PP, Luo JY, Jiang YW, Zhang H, Wan HF, Wang XG, Wu FK, Tao WA, He XJ, Du JM*, Zhu JK*. (2018) Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin. Nature Communications , 9, 4547   

  3.   Tan LM#, Zhang CJ#, Hou XM, Shao CR, Li YQ, Li L, Cai T, Chen S, He XJ*. (2018) The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing. EMBO Journal , 37, e100573     

  3.   Zhang CJ#, Hou XM#, Tan LM, Shao CR, Huang HW, Li YQ, Li L, Cai T, Chen S, He XJ*. (2016) The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing. Nature Communications , 7,11715

  4.   Zhang CJ#, Zhou JX#, Liu J#, Ma ZY, Zhang SW, Dou K, Huang HW, Cai T, Zhu JK, He XJ*. (2013) The splicing machinery promotes RNA-directed DNA methylation and transcriptional silencing in Arabidopsis . EMBO Journal , 32, 1128-40.

  5.   Zhang CJ, Ning YQ, Zhang SW, Chen Q, Shao CR, Guo YW, Zhou JX, Li L, Chen S, He XJ*. (2012) IDN2 and its paralogs form a complex required for RNA-directed DNA methylation. PLoS Genetics , 8, e1002693.

  6.   Liu J#, Bai G#, Zhang CJ#, Chen W, Zhou JX, Zhang SW, Chen Q, Deng X, He XJ*, and Zhu JK. (2011) An atypical component of RNA-directed DNA methylation machinery has both DNA methylation-dependent and-independent roles in locus-specific transcriptional gene silencing. Cell Research , 21, 1691-1700.

  7.   Zhang CJ, and Guo Y*. (2012) OsTRXh1 regulates the redoxstate of the apoplast and influences stress responses in rice. Plant Signal Behav ., 7, 441-443.

  8.   Zhang CJ#, Zhao BC#, Ge WN, Zhang YF, Song Y, Sun DY, and Guo Y*. (2011) An apoplastic h-type thioredoxin is involved in the stress response through regulation of the apoplastic reactive oxygen species in rice. Plant Physiol ., 157, 1884-1899.

  9.   Song Y#, Zhang CJ#, Ge WN, Zhang YF, Burlingame AL, and Guo Y*. (2011) Identification of NaCl stress-responsive apoplastic proteins in rice shoot stems by 2D-DIGE. J Proteomics , 74, 1045-1067.

  张翠军课题组更新于2021年5月

Baidu
sogou
Baidu
sogou
TOP
Baidu
sogou