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唐中林课题组

  唐中林课题组

  Tang Zhonglin Lab

  课题组长

  唐中林,研究员,博士生导师。中国农业科学院农业基因组研究所首席科学家,动物基因组研究中心主任,2016年入选国家重大人才工程领军人才。2016年在哈佛大学做访问学者。承担国家自然科学基金重点及面上项目、973子课题、863重点和转基因重大专项等国家级课题10余项,在Genome Biology、Nucleic Acid Research、DNA Research等刊物发表SCI论文70余篇,获国家技术发明二等奖、省科技进步奖、中华农业科技奖、国家专利银奖等多项国家及省部级奖,获国家发明专利17项,软件著作权23项,国际发明专利2项。

  

  工作经历

  2017.6至今             中国农业科学院农业基因组研究所                  研究员、中心主任       

  2015.9-2016.8        哈佛大学                                                       访问学者

  2014.1-2017.5       中国农业科学院畜牧兽医研究所                      研究员

  2008.7-2013.12     中国农业科学院畜牧兽医研究所                      副研究员

  2006.7-2008.6       中国农业科学院畜牧兽医研究所                      博士后

 

  教育经历

  2001.9-2006.6         华中农业大学              博士       

  1994.9-1998.6         华中农业大学              学士       

  

  研究方向

  综合利用高通量的基因组、转录组、代谢组、蛋白组等多种组学技术和精准基因编辑技术,解析猪和小鼠等动物骨骼肌生长发育和重要经济性状形成的分子机制;利用生物信息、分子和细胞生物学等手段,在分子、细胞和个体水平,阐明骨骼肌生长发育相关基因和非编码RNA的功能和表达调控机制。

  

  研究进展

  重要进展成果1:公布首个中国地方猪“超清”基因组图谱,提供亚洲地方品种陆川猪参考基因组序列;

  重要进展成果2:整合多组学方法和全基因组关联分析鉴定出多个产肉性状密切相关的基因标记;

  重要进展成果3:首次建立猪全基因组RNA编辑位点、猪骨骼肌甲基化等多个数据库。

  

  PI

  Prof. Zhonglin Tang, Doctoral Advisor, research Professor of Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences (CAAS-AGIS), Director of the Animal Genomics Research Center. Prof. Zhonglin Tang has been honored as a leader talent of National “Ten Thousand Talent Program” and visited Harvard University as a visiting scholar in 2016. Prof. Zhonglin Tang has undertaken more than 10 projects supported by Natural Science Foundation of China, including the National Key Project, 973 Sub-topics, etc. More than 70 journal articles were published on prestigious journals, e.g., Genome Biology, Nucleic Acid Research, DNA Research . His team achieved the National Technology Invention Award, Provincial Science and Technology Progress Award, China Agricultural Science and Technology Award, National Patent Silver Award and other national and provincial awards. He also obtained 17 national invention patents, 23 software copyrights and 2 international patents.

  

  Working Experience

  2017.6–Present               Agricultural Genomics Institute at Shenzhen-CAAS               research Professor,Center director                

  2015.9–2016.8               Harvard University                                                                    visiting scholar                                                 

  2014.1–2017.5               Institute of Animal Sciences -CAAS                                        research Professor

  2008.7–2013.12             Institute of Animal Sciences -CAAS                                        associate professor         

  2006.7–2008.6               Institute of Animal Sciences -CAAS                                        Postdoctoral Fellow    

  

  Education Experience

  2001.9-2006.6              Huazhong Agricultural University                          Ph.D                   

  1994.9-1998.6              Huazhong Agricultural University                          Bachelor           

  

  Research Interest

  Using high-throughput genomics, transcriptomics, metabolomics, proteomics, and gene-editing techniques to understand the molecular mechanisms underlying skeletal muscle growth and development in pigs and mice; Using biological information, molecular and cellular biology to elucidate the function and expression regulation mechanisms of skeletal muscle growth and development related genes and non-coding RNAs at the molecular, cellular and individual levels.

  

  Major Achievements

  Published the first "ultra-clear" genomic map of Chinese local pigs(Luchuan pig), and provided the reference genome sequence of Asian local breeds.

  Identified multiple genetic markers closely related to meat production traits by Integrated the multi-omics method and genome-wide association analysis Significant Progress.

  Established the world's first database of pig genome genome RNA editing site and pig skeletal muscle methylation.

  

  Selected Publication

  1. Yalan Yang, Xinhao Fan, Junyu Yan, Muya Chen, Min Zhu, Yijie Tang, Siyuan Liu, ZhongLin Tang*. A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development. Nucleic Acid Research , 2020, doi: 10.1093/nar/gkaa1203.  

  2.  Xinxin Zhang, Yilong Yao, Jinghua Han, Yalan Yang, Yun Chen, ZhongLin Tang*, Fei Gao*. Longitudinal epitranscriptome profiling reveals the crucial role of N6-methyladenosine methylation in porcine prenatal skeletal muscle development, Journal of Genetics and Genomics , 2020, 47 (2020) 466-476.  

  3.  YongSheng Zhang, YiLong Yao, ZiShuai Wang, Dan Lu, YuanYuan Zhang, Adeyinka Abiola Adetula, SiYuan Liu, Min Zhu, YaLan Yang, XinHao Fan, MuYa Chen, YiJie Tang, Yun Chen, YuWen Liu, GuoQiang Yi, ZhongLin Tang*. MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration. Genes & Diseases , 2020, .  

  4. Liang, G.; Yan, J.; Guo, J.; Tang, Z*. Identification of Ovarian Circular RNAs and Differential Expression Analysis between MeiShan and Large White Pigs. Animals 2020, 10, 1114.  

  5. Zhang yongsheng ,Lu dan, Liu Yuwen, Yi guoqiang, Tang zhonglin*. The untold story between enhancers and skeletal muscle development. Journal of Integrative Agriculture , 2020, 19(0):2-14. 

  6. Yalan Yang, Min Zhu, Xinhao Fan, Yilong Yao, Junyu Yan, Yijie Tang, Siyuan Liu, Kui Li*,and Zhonglin Tang*. Developmental atlas of the RNA editome in Sus scrofa skeletalmuscle. 2019, DNA Research , 2019.  26(3):261-272

  7. Z Wang*, Y Yang*, S Li, K Li and Z Tang*. Analysis and comparison of long non-coding RNAs expressed in the ovaries of Meishan and Yorkshire pigs.  Animal Genetics ,2019,50(6):660-669.

  8. Muya Chen†, Yi Long Yao†, Yalan Yang, Min Zhu, Yijie Tang, Siyuan Liu, Kui Li and Zhonglin Tang*. Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs.  Front. Genet ,2019, 10:10.3389

  9. Zishuai Wang,Xikang Feng,Zhonglin Tang* and Shuai Cheng Li*. Genome-Wide Investigation and Functional Analysis of Sus scrofa RNA Editing Sites across Eleven Tissues. 2019, Genes , 10(7):10.3390

  10. Li Zhang, Yuemeng Huang,Meng Wang, Yafen Guo, Jing Liang,* Xiurong Yang, Wenjing Qi,Yanjun Wu, Jinglei Si, Siran Zhu, Zhe Li, Ruiqiang Li, Chao Shi,* Shuo Wang, Qunjie Zhang,Zhonglin Tang, Lixian Wang, Kui Li, Ji-Feng Fei, and Ganqiu Lan*Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease,  iScience , 2019, 19:162-176

  11. Xiaofei Yu, Zishuai Wang, Hao Sun, Guanglin Niu, Kui Li and Zhonglin Tang*.Identify long non-coding MEG3 as a candidate for skeletal muscle development and meat production traits in pigs.  Animal Genetics , 2018, 49(6):571-578.

  12. Guoming Liang, Yalan Yang, Hua Li, Hui Yu, Xunbi Li, Zhonglin Tang* and Kui Li*.LncRNAnet: a comprehensive sus scrofa lncRNA database.  Animal Genetics , 2018, 49(6):632-635.

  13. Guoming Liang, Yalan Yang, Guanglin Niu, Zhonglin Tang*, and Kui Li*.Genome-wide profiling of Sus scrofa circular RNAs across 9 organs and 3 developmental stages,  DNA Research , 2017,24(5):523-535.

  14. Jing Zhang, Zhengzhou Ying, Zhonglin Tang*, Liangqi Long, Kui Li.MicroRNA-148a promotes myogenic differentiation by targeting the ROCK1. Journal of Biological Chemistry . 2012,287 ( 25 ): 21093-101

  15. Zhonglin Tang, Yong Li, Ping Wan, Xiaoping Li, Shuhong Zhao, Bang Liu, Bin Fan, Mengjin Zhu, Mei Yu, Kui Li. LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigs.  Genome Biology . 2007.8(6):R115

  

  Selected Patent

  1.唐中林,李奎,化朝举/一种基于SMAD7基因的猪活体背膘厚标记辅助选择方法/2019-02-26/中国

  2. 唐中林,李奎,赵栓平,任红艳/与猪免疫性状相关的蛋白及其编码基因及应用/2013-06-12/中国

  3. 唐中林,李奎,梁如意,周荣,杨述林,敖红,牟玉莲,崔文涛/辅助评价仔猪初生重和断奶重的方法及其专用引物/2013-11-13/中国

  4. 唐中林,孙浩,李奎,梁如意/一种鉴定或辅助鉴定猪达100kg体重日龄的方法及其专用试剂盒/2018-11-27/中国

  5. 李奎,唐中林,孙浩,梁如意/一种鉴定或辅助鉴定猪100Kg体重眼肌面积的方法及其专用试剂盒/2018-08-17/中国

  6. 李奎,鞠辉明,樊俊华,白立景,牟玉莲,杨述林,唐中林/一种制备同时表达多个基因的转基因动物的方法/2011-12-14/中国

  7.Kui Li, Huiming Ju, Junhua Fan, Lijing Bai, Yulian Mu, Shulin Yang, Zhonglin Tang, WentaoCui/Methold for preparing a transgenic animal of simultaneous multiple-gene expression/2012-09-13/国际专利

  8. 李奎,李勇,唐中林,杨述林/一种检测猪肉质性状的方法/2010-12-15/中国

  9. 李奎,刘华珍,李新云,唐中林,杨述林,崔文涛/一种猪免疫性状相关蛋白及其编码基因与应用/2010-06-02/中国

  10.敖红,张宁波,李奎,李勇,唐中林,杨述林,储明星/检测猪的抗猪瘟病性状的方法及其专用试剂盒/2013-02-06/中国

  

  唐中林课题组更新于2021年3月

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