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Yuxiao Chang Lab


  常玉晓,研究员,博士生导师。中国农科院“青年英才”,深圳市“海外高层次人才”。2009年毕业于华中农业大学作物遗传改良国家重点实验室,获理学博士学位。2010-2015年先后在美国The Wistar Institute和The Jackson Lab for Genomic Medicine从事肿瘤基因组学研究。目前主要研究领域为新一代测序技术的开发及应用和产业化,已经成功开发出多种新的DNA测序相关方法并申请了专利。近五年以第一/通讯作者在国际学术期刊上发表学术论文5篇。



  2015.2---至今         新萄京3522vip         研究员       

  2012.10--2015.1    美国杰克逊基因组医学实验室                       博后                                                                                                                         2010.5---2012.9     美国维斯塔研究所                                  博后 



  2002.9-2009.12          华中农业大学              理学博士                

  1997.9-2001.7            河南农业大学              农学学士         



  新一代测序技术(Next Generation Sequencing, NGS)的快速发展已经深深的影响了植物功能基因组学和育种研究的方方面面。随着测序技术的不断成熟以及价格的不断下降,未来NGS一定会与植物功能基因组学和育种研究结合的更加紧密。我们的研究方向主要是基于NGS,开发为植物功能基因组学和育种研究服务的新方法,主要包括:第一,DNA大片段文库的制备;第二,全基因组分子标记的新方法;第三,这些新技术在复杂植物基因组中的应用,尤其是玉米抗病基因定位与克隆中的应用。



  改良了Fosmid文库的构建方法,大大提高了Fosmid文库的构建效率; 开发了高效的重测序文库构建方法AIO-seq,简化了实验流程,降低了测序总成本。



  Yuxiao Chang is a Principle Investigator and Doctoral Advisor at Agricultural Genomics Institute at Shenzhen , Chinese Academy of Agricultural Sciences (CAAS). He has been honored as “Outstanding Young talents of CAAS”, and “Shenzhen Overseas Senior Talents”. Dr Chang graduated from National Key Laboratory of Crop Genetic Improvement and obtained his PhD degree in Biology from Huazhong Agricultural University in 2009. During 2010-2015, he was mainly engaged in the research of the Cancer Genome at The Wistar Institute and The Jackson Lab for Genomic Medicine in America. Currently, He has been focusing on the development of some novel Next Generation Sequencing (NGS) methods and subsequent application and industrialization. During the last five years, he has successfully developed a variety of novel methods on DNA sequencing, applied for several sequencing-related patents, and published five papers on international academic journals where he served as co-first author or co-corresponding author.


  Working Experience

  2015.2–Present       Agricultural Genomics Institute at Shenzhen-CAAS         Professor                                                                      

  2012.10–2015.1      The Jackson Laboratory for Genomics Medicine               Postdoctoral fellow     

  2010.5–2012.9        The Wistar Institute fellow                                                  Postdoctoral fellow                               


  Education Experience

  2002.9–2009.12            Huazhong Agricultural University              Ph.D                    

  1997.9–2001.7              Henan Agricultural University                    Master                 


  Research Interest

  The rapid progress of Next Generation Sequencing (NGS) technology has greatly revolutionized the multiple research fields of plant functional genomics and breeding. With the rapid decrease in cost and increasing ability to generate sequencing data, NGS technology will be more widely applied in these fields in near future. So, the main aim of Chang’s lab is to develop some novel sequencing methods for plant functional genomics and breeding using NGS technology, including: 1) the methods to prepare the large-insert genomic library; 2) the methods for whole genome genotyping; 3) the application of newly developed methods in complex plant genome, particularly the mapping and cloning of resistant gene in maize.


  Major Achievements

  (1)   Developed an improved method for large size DNA recovery which facilitated the Fosmid library preparation;

        (2)   Developed an improved library preparation method, namely all-in-one sequencing, for cost effective and high-throughput next-generation sequencing.


  Selected Publication

  1. Hui Zhang#, Yuexing Wang#, Ce Deng, Sheng Zhao, Peng Zhang, Jie Feng, Wei Huang, Shujing Kang, Qian Qian, Guosheng Xiong*, Yuxiao Chang*. High-quality genome assembly of Huazhan and Tianfeng, the parents of an elite rice hybrid Tian-you-hua-zhan, SCIENCE CHINA Life Sciences, 2021, doi: 10.1007/s11427-020-1940-9.

  2.Xinchao Wang#, Hu Feng#, Yuxiao Chang#, Chunlei Ma#, Liyuan Wang#, Xinyuan Hao#, A’lun Li, Hao Cheng , Lu Wang, Peng Cui, Jiqiang Jin, Xiaobo Wang, Kang Wei, Cheng Ai, Sheng Zhao, Zhichao Wu, Youyong Li, Benying Liu, Guodong Wang*, Liang Chen*, Jue Ruan*, Yajun Yang*. Population sequencing enhances understanding of tea plant evolution, Nature communications, 2020, 11(1):4447

  3. Sheng Zhao#, Cuicui Zhang#, Jiangqiang Mu, Hui Zhang, Wen Yao, Xinhua Ding, Junqiang Ding*, Yuxiao Chang*. All-in-one sequencing: an improved library preparation method for cost-effective and high-throughput next-generation sequencing, Plant Methods, 2020, 16:74.

  4. Meng Lv, Ce Deng, Xueying Li, Xiaodi Zhao, Huimin Li, Zhimin Li, Zhiqiang Tian, April Leonard, Jennifer Jaqueth , Bailin Li, Junjie Hao, Yuxiao Chang, Junqiang Ding*. Identification and fine-mapping of Rppcml496, a major QTL for resistance to Puccinia polysora in maize, The Plant Genome, 2020, e20062

  5. Ping Li#, Haoju Liu#, Hong Yang, Xiaojun Pu, Chuanhong Li, Heqiang Huo, Zhaohui Chu, Yuxiao Chang, Yongjun Lin*, Li Liu*. Translocation of Drought-Responsive Proteins from the Chloroplasts, Cells 2020, 9(1), 259.

  6. Ce Deng, Huimin Li, Zhimin Li, Zhiqiang Tian, Jiafa Chen, Gengshen Chen, Xuecai Zhang, Junqiang Ding*, Yuxiao Chang*. New QTL for resistance to Puccinia polysora  Underw in maize, Journal of Applied Genetics, 2019, 60: 147-150.

  7. Changsong Zou, Leiting Li, Daisuke Miki, Deli Li, Qiming Tang, Lihong Xiao, Santosh Rajput, Ping Deng, Li Peng, Wei Jia, Ru Huang, Meiling Zhang, Yidan Sun, Jiamin Hu, Xing Fu, Patrick S. Schnable, Yuxiao Chang, Feng Li, Hui Zhang, Baili Feng, Xinguang Zhu, Renyi Liu, James C. Schnable, Jiankang Zhu*, Heng Zhang*. The genome of broomcorn millet, Nature Communications, 2019, 10(1): 436-446.

  8. Zhiyong Li, Yifeng Wang, Babatunde Kazeem Bello, Abolore Adijat Ajadi, Xiaohong Tong, Yuxiao Chang*, Jian Zhang*. Construction of a Quantitative Acetylomic Tissue Atlas in Rice (Oryza sativa  L.), Molecules, 2018, 23(11): 2843-2859.

  9. Xingwang Li, Yuxiao Chang, Xiaodong Xin, Chunmei Zhu, Xianghua Li, James D Higgins, Changyin Wu*. Replication protein A2c coupled with replication protein A1c regulates crossover formation during meiosis in rice, Plant Cell, 2013, 25(10): 3885-3899.

  10. Yuxiao Chang, Tuan Long, Changyin Wu*. Effort and contribution of T-DNA Insertion mutant library for rice functional genomics research in China: review and perspective, Journal of Integrative Plant Biology, 2012, 54(12): 953-966.

  11. Yanjun Kou, Yuxiao Chang, Xianghua Li, Jinghua Xiao, Shiping Wang*. The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells, Journal of Experimental Botany, 2012, 63(14): 5323-5335.

  12. Yuxiao Chang, Liang Gong, Wenya Yuan, Xingwang Li, Guoxing Chen, Xianghua Li, Qifa Zhang, Changyin Wu*. Replication protein A (RPA1a) is required for meiotic and somatic DNA repair but is dispensable for DNA replication and homologous recombination in rice, Plant Physiology, 2009, 151(4): 2162-2173.

  13. 张翠翠#,赵胜#,王越,张鹏,常玉晓*. 利用高效的大片段 DNA 回收方法改良 Fosmid 文库的构建,生物技术通报,2020, 36(7):17-23.


  Selected Patent