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李素华课题组

李素华课题组

Li Suhua Lab

  课题组长

  李素华,研究员,博士生导师,深圳市海外高层次人才。2017年于清华大学获得博士学位,2017-2020年在德国马克斯·普朗克化学生态所进行博士后研究。长期从事植物植物激素信号传导和次生代谢调控研究。共发表SCI收录论文10篇以上。以第一作者或通讯作者(含共同)在Nature、Molecular Plant、PLoS Biology、Plant Physiology、Plant Journal等国际高水平杂志共发表论文6篇。博士后期间获得德国洪堡基金会的资助。引进农科院后,获得2020年国家重点研发计划项目资助。联系方式:lisuhua01@caas.cn。

 

 

  工作经历

  2020.6 - 至今       中国农科院深圳农业基因组研究所      研究员

  2017.4 - 2020.06     德国马普化学生态所                      博士后

 

 

  教育经历

  2010.9 - 2017.1      清华大学   博士

  2006.9 - 2010.9      中国农业大学   学士

 

 

  研究方向

  植物次生代谢物在调控植物的生长发育、抵抗逆境胁迫、介导植物和其他生物的互作等方面具有重要作用,其中多种植物天然产物具有农业与药用价值。本课题组将利用基因组学和代谢组学分析,结合分子生物学、遗传学手段,研究植物激素如茉莉素和独脚金内酯对经济植物如马铃薯、烟草等次生代谢产物的调控,进而影响植物的抗虫能力、与根系菌群互作能力的分子机理。

 

 

  研究进展

  该课题组长期从事植物激素信号通路与植物代谢物研究,与其合作者共同揭示了新型植物激素独脚金内酯的受体感知和信号传导机制。并进一步对其生物学功能进行了研究,发现了独脚金内酯通过和其他多种激素互作共同调控多种植物代谢物的含量,从而促进植物抵御虫害,响应逆境胁迫的重要功能。且开发了多种新型独脚金内酯和茉莉素相关的高活性人工合成分子,具有较高的潜在农业应用价值。

 

 

  PI

  Suhua Li, Principle Investigator. She received her Ph.D. degree in Biology from Tsinghua University in 2017. She subsequently worked as a postdoctoral researcher at Max Planck Institute for Chemical Ecology in Germany. She mainly focuses on exploring the function and the molecular mechanism of the transduction of plant hormones, as well as the regulatory mechanism of plant hormones on secondary metabolites. She has published more than 10 SCI papers. As the first author or co-first-author, she has published 6 papers in Nature, Molecular Plant, PLoS Biology, Plant Physiology and Plant Journal etc. She was awarded as an alumni member of Alexander von Humboldt Foundation, thus she can host Humboldt applicants from Germany. Email address: lisuhua01@caas.cn.

 

 

  Working Experience

  2020.6 – present     Agricultural Genomics Institute at Shenzhen - CAAS         Principal Investigator

  2017.4 - 2020.6    Max Planck Institute for Chemical Ecology          Postdoctor

 

 

  Education

  2010.9 - 2017.1      Tsinghua University                                                                 PhD

  2006.9 – 2010.7      China Agricultural University                                                 Bachelor

                          

 

  Research Interest

  Plant secondary metabolites play essential roles in plant development, defense on biotic and abiotic stresses and interactions with other organisms, and constitute a valuable resource for commercial applications in pharmaceuticals and agrochemicals. By taking advantage of genomics, metabolomics with genetic methods, our group focuses on elucidating the roles of plant hormones such as strigolactones and jasmonates in regulating the biosynthesis of secondary metabolites, which consequently affects the growth and production of the economic plants such as tomato and potato. Furthermore, we are interested in understanding the mechanism of how the changes of metabolism triggered by these hormones may affect the interplay between the host plants with rhizosphere microbes.

  

 

  Major Achievements

  Plant hormones control plant growth and development, pathogen and herbivore defense, as well as stress tolerance. We work on two kinds of plant hormones, jasmonates and strigolactones, to reveal the molecular mechanisms of their signal transduction, and to investigate their regulatory functions on plant secondary metabolites. Together with collaborators, we revealed the perception mechanism of strigolactones with the receptors and the structure-activity relationships of strigolactones. We further investigated the ecological and physiological functions of strigolactones, such as regulating herbivore defense via manipulating defensive metabolites. In addition, we designed a serious of highly active jasmonate- and strigolactone-analogs, which are with potential possibility of agricultural applications.

 

 

  Selected Publication

       1. Suhua Li, Youngsung Joo, Dechang Cao, Ran Li, Gisuk Lee, Rayko Halitschke, Gundega Baldwin, Ian T. Baldwin and Ming Wang.  Strigolactone signaling regulates specialized metabolism in tobacco stems and interactions with stem-feeding herbivores. PLoS Biology, 2020, 18(8): e3000830.

       2. Ruifeng Yao*, Zhenhua Ming*, Liming Yan*, Suhua Li*, Fei Wang, Sui Ma, Caiting Yu, Mai Yang, Li Chen, Linhai Chen, Yuwen Li, Chun Yan, Di Miao, Zhongyuan Sun, Jianbin Yan, Yuna Sun, Lei Wang, Jinfang Chu, Shilong Fan, Wei He, Haiteng Deng, Fajun Nan, Jiayang Li, Zihe Rao, Zhiyong Lou, Daoxin Xie. DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 2016, 536: 469-473(* co-first-author).

       3. Suhua Li*, Linhai Chen*, Yuwen Li, Ruifeng Yao, Fei Wang, Mai Yang, Min Gu, Fajun Nan, Daoxin Xie, Jianbin Yan. Effect of GR24 stereoisomers on plant development in Arabidopsis. Molecular Plant, 2016, 10(9): 1432-1435.

       4. Jianbin Yan*, Suhua Li*, Min Gu, Ruifeng Yao, Yuwen Li, Juan Chen, Mai Yang, Jianhua Tong, Langtao Xiao, Fajun Nan, Daoxin Xie. Endogenous bioactive jasmonate is composed of a set of (+)-7-iso-JA-amino acid conjugates. Plant Physiology, 2016, 172(4): 2154-2164.

       5. Suhua Li *, Yuwen Li*, Linhai Li*, Chi Zhang, Fei Wang, Haiou Li, Ming Wang, Yupei Wang, Fajun Nan, Daoxin Xie, Jianbin Yan. (2021). Strigolactone mimic 2-nitrodebranone is highly active in Arabidopsis growth and development. Plant Journal, 107, 67–76.

       6. Yuwen Li*, Suhua Li *†, Ran Du, Jiaojiao Wang, Haiou Li, Daoxin Xie†, and Jianbin Yan† (2021) Isoleucine enhances plant resistance against Botrytis cinerea via jasmonate signaling pathway. Frontiers in Plant Science, August 19 († corresponding author).

       7. Ming Wang, Martin Schäfer, Dapeng Li, Rayko Halitschke, Dong Chuanfu, Erica McGale, Christian Paetz, Yuanyuan Song, Suhua Li, Junfu Dong, Sven Heiling, Karin Groten, Philipp Franken, Michael Bitterlich, Maria J Harrison, Uta Paszkowski, Ian T Baldwin. Blumenols as shoot markers of root symbiosis with arbuscular mycorrhizal fungi. eLife, 2018, 7:e37093.

       8. Jianbin Yan, Ruifeng Yao, Li Chen, Suhua Li, Min Gu, Fajun Nan, Daoxin Xie. Dynamic perception of jasmonates by the F-box protein COI1. Molecular Plant, 2018, 11: 1237-1247.

       9. Ruifeng Yao, Lei Wang, Yuwen Li, Li Chen, Suhua Li, Xiaoxi Du, Bing Wang, Jianbin Yan, Jiayang Li, Daoxin Xie. Rice DWARF14 acts as an unconventional hormone receptor for strigolactone. Journal of Experimental Botany, 2018, 69: 2355-2365.

       10. Haiou Li, Ruifeng Yao, Sui Ma, Shuai Hu, Suhua Li, Yupei Wang, Chun Yan, Daoxin Xie, Jianbin Yan. Efficient ASK-assisted system for expression and purification of plant F-box proteins. The Plant Journal, 2017, 92(4): 736-743.

       11. Jianbin Yan, Haiou Li, Suhua Li, Ruifeng Yao, Haiteng Deng, Qi Xie, Daoxin Xie. The Arabidopsis F-Box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. The Plant Cell, 2013, 25: 486-498.

       *Co-first author, #Corresponding author

  李素华课题组更新于2021年2月

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