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胡冠菁课题组

  胡冠菁课题组

  Hu, Guanjing Lab

  

  课题组长

  胡冠菁, 所聘研究员。2006年本科毕业于北京大学,2013年博士毕业于美国爱荷华州立大学。2013至2020年继续在美国爱荷华州立大学生态、进化及有机生物学系Jonathan F. Wendel实验室从事棉属植物的进化遗传学和功能基因组学研究。迄今已在国际学术期刊发表论文20多篇,其中近五年来以第一作者在Nature CommunicationsNew PhytologistsGeneticsGenome Biology and Evolution Briefings in Bioinformatics期刊上发表5篇关于棉属基因遗传调控和⽹络分析的研究和综述⽂章。主要研究领域为棉属植物的进化系统生物学与遗传育种。

  

  工作经历

  2020/09-至今            中国农业科学院棉花研究所及(深圳)农业基因组研究所,研究员

  2018/09-2020/08     美国爱荷华州立大学, 助理科学家

  2013/08-2018/08     美国爱荷华州立大学, 博士后

  

  学习经历

  2006/09-2013/08       美国爱荷华州立大学, 遗传学, 博士

  2002/09-2006/06       中国北京大学, 生物技术, 本科

  

  研究方向

  本团队将整合多维度与多组学研究手段,以棉属植物的进化系统生物学与遗传育种为主要科研方向,深⼊系统地研究棉花纤维发育、棉籽油份合成、胁迫响应等重要⽣理机制在多倍化和驯化过程中的进化机制以及相关功能基因的表达调控基础。通过对染色体结构、转录调控元件、以及动态转录谱的系统分析,我们将致力于解析复杂农艺性状的基因遗传⽹络与干预机制。

  

  PI

  Dr. Guanjing Hu, Principle Investigator. Her lab focuses on evolutionary systems biology of polyploidization that underlies phenotypic evolution, crop domestication and improvement in cotton. At a broader scale, the lab will approach classical systems biology questions within an evolutionary framework and aim to develop innovations for modern plant breeding.

  

  Research Experience

  2020/09-present:Institute of Cotton Research, Chinese Academy of Agricultural Sciences; Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences; Principle Investigation

  2018/09-2020/08: Iowa State University (US), Assistant Scientist

  2013/08-2018/08: Iowa State University (US), Postdoctoral Research Association

  

  Education

  2006/09-2013/08: Iowa State University (US), Genetics, PhD

  2002/09-2006/06:Peking University (US), Biotechnology, Bachelor

  

  

  Research Interest

  Our research program integrates multi-level and multi-omics methods to approach classical systems biology questions within an evolutionary framework, and to develop innovations for modern plant breeding. Using the cotton genus Gossypium as a model system, we aim to enable insights into the evolution of genomic and epigenomic architecture, the functional genomics of polyploid genomes, the complexities of the genotype-to-phenotype equation, and agricultural breeding applications.

  

  

  Selected Publication (#Co-first-author)

  1. Hu, G., C. E. Grover, M. A. I. I. Arick, M. Liu, D. G. Peterson et al., 2020 Homoeologous gene expression and co-expression network analyses and evolutionary inference in allopolyploids. Brief. Bioinform. bbaa35.

       2. #Bao, Y., #G. Hu, C. E. Grover, J. Conover, D. Yuan et al., 2019 Unraveling cis and trans regulatory evolution during cotton domestication. Nat. Commun. 10: 5399.

      3. Hu, G., and J. F. Wendel, 2018 Cis-trans controls and regulatory novelty accompanying allopolyploidization. New Phytologist 221: 1691–1700.

      4. Dong, Y., G. Hu, J. Yu, S. W. Thu, C. E. Grover et al., 2019 Salt‐tolerance diversity in diploid and polyploid cotton (Gossypium) species. Plant J. 101: 1135-1151.

      5. #Zhao, B., #J. F. Cao, #G. Hu, Z. W. Chen, L. Y. Wang, X. X. Shangguan, Ling-Jian Wang, Y. B. Mao, T. Z. Zhang, J. F. Wendel, X. Y. Chen. 2018. Core cis-element variation confers subgenome-biased expression of a transcription factor that functions in cotton fiber elongation. New Phytologist 218(3):1061-1075.

      6. Hu, G., R. Hovav, C. E. Grover, A. Faigenboim-Doron, N. Kadmon et al., 2016 Evolutionary conservation and divergence of gene co-expression networks in Gossypium (cotton) seeds. Genome Biol. Evol. 8: 3765–3783.

      7. Hu, G., J. Koh, M.-J. Yoo, S. Chen, and J. F. Wendel, 2015 Gene-expression novelty in allopolyploid cotton: a proteomic perspective. Genetics 200: 91–104.

     8. Hu, G., J. Koh, M.-J. Yoo, D. Pathak, S. Chen et al., 2014 Proteomics profiling of fiber development and domestication in upland cotton (Gossypium hirsutum L.). Planta 240: 1237–1251.

      9. Hu, G., J. Koh, M.-J. Yoo, K. Grupp, S. Chen et al., 2013 Proteomic profiling of developing cotton fibers from wild and domesticated Gossypium barbadense. New Phytol. 200: 570–582.

      10. Hu, G., N. L. Houston, D. Pathak, L. Schmidt, J. J. Thelen et al., 2011 Genomically biased accumulation of seed storage proteins in allopolyploid cotton. Genetics 189: 1103–1115.

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