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创新团队

  

  农业生物转录组与代谢组创新团队

  Agricultural Transcriptomics and Metabolomics Innovation Group

  

  研究方向  

  植物天然产物生物合成与代谢调控的分子机制,对于农作物的品质改良、合成生物学制造、个性化食品以及中医药开发等国家重大需求,均具有重要的意义。团队综合利用合成生物学理念和多组学大数据分析手段,整合基因组、转录组、蛋白质组及代谢组等信息,聚焦多组学分子网络的大数据挖掘与利用和重要代谢分子的生物途径解析与人工设计,实现重要活性天然产物的高效发现、机制解析、定向设计、生物制造和品种改良育种的潜能释放。

  

  团队构成  

  团队汇聚了多位从事植物代谢、天然产物合成途径解析、植物激素信号转导、合成生物学智造、代谢组技术开发和生物大数据分析等跨学科的青年创新人才,平均年龄30岁。团队成员朝气蓬勃、锐意创新、勇于担当、团结互助,力争为解决植物代谢前沿问题、推动农业合成生物学发展与国家农业重大需求贡献力量。

  

  团队成员代表论文  

  1. Yang X, Yan J, Zhang Z, Lin T, Xin T, Wang B, Wang S, Zhao J, Zhang Z, William J, Li G, Huang S. Regulation of plant architecture by a novel histone acetyltransferase targeting gene bodies. Nature Plant, 2020, 6, 809-822.

  2. Liao Q, Du R, Gou J, Guo L, Shen H, Liu H, Nguyen J, Ray M, Yin T, S. Huang S and Yan J. The genomic architecture of sex determining region and sex-related metabolic variation in Ginkgo biloba. The Plant Journal, 2020, doi.org/10.1111/tpj.15009.

  3. Li C, Ong K, Cui Z, Sang Z, Li X, Patria R, Qi Q, Fickers P, Yan J and Lin C. Promising advancement in fermentative succinic acid production by yeast hosts, Journal of Hazardous Materials, 2020, 401, 123414.

  4. Li, C., Chen, C., Wu, X., Tsang, C.W., Mou, J., Yan, J., Liu, Y., Lin, C.S.K., 2019. Recent advancement in lignin biorefinery: with special focus on enzymatic degradation and valorization. Bioresource Technology. 121898.

  5. Li, C., Ong, K.L., Yang, X., Lin, C.S.K. 2019. Bio-refinery of waste streams for green and efficient succinic acid production by engineered Yarrowia lipolytica without pH control. Chemical Engineering Journal. 371, 804-812.

  6. Li, C., Yang, X., Gao, S., Lin, C.S.K., 2018. Hydrolysis of fruit and vegetable waste for efficient succinic acid production with engineered Yarrowia lipolytica. Journal of Cleaner Production. 179, 151-159.

  7. Li, C., Gao, S., Yang, X., Lin, C.S.K., 2017. Green and sustainable succinic acid production from crude glycerol by engineered Yarrowia lipolytica via agricultural residue based in situ fibrous bed bioreactor. Bioresource Technology. 249, 612-619.

  8. Li, C., Yang, X., Gao, S., Wang, H., Lin, C.S.K., 2017. High efficiency succinic acid production from glycerol via in situ fibrous bed bioreactor with an engineered Yarrowia lipolytica. Bioresource Technology. 225, 9-16.

  9. Liu, Y., Li, C., Wang, S., Chen, W., 2014. Solid-supported microorganism of Burkholderia cenocepacia cultured via solid state fermentation for biodiesel production: Optimization and kinetics. Applied Energy. 113, 713-721.

  10. Li W, Daniel B., Zhou F, Robert L., Eran P. Pyrethrin biosynthesis: The cytochrome P450 oxidoreducatse CYP82Q3 converts jasmolone to pyrethrolone. Plant Physiology, 2019,181: 934–944.

  11. Xu H, Li W, Anthony L., Henriëtte E., Ric C., Maarten A., Eran P. Pyrethric acid of natural pyrethrin insecticide: complete pathway elucidation and reconstitution in Nicotiana benthamiana. New Phytologist, 2019, 223: 751–765.

  12. Zhu G, Wang S, Huang Z, Zhang S, Liao Q, Zhang C, Lin T, Qin M, Peng M, Yang C, Cao X, Han X, Wang X, Esther K., Zhang Z, Cui X, Harry K., Alisdair R., Luo J, Huang S, Rewiring of the Fruit Metabolome in Tomato Breeding, Cell, 2018, 172, 1, 249-261

  13. Wu R, Zhang F, Liu L, Li W, Eran P., Wang G. MeNA, controlled by reversible methylation of nicotinate, is an NAD precursor that undergoes long-distance transport in Arabidopsis. Molecular Plant,2018, 11: 1264-1277.

  14. Li W, Zhou F, Eran P. Jasmone hydroxylase, a key enzyme in the synthesis of the alcohol moiety of pyrethrin insecticides. Plant Physiology, 2018, 177: 1498-1509.

        15. Yan J, Yao R, Chen L, Li S, Gu M, Nan F, Xie D. Dynamic perception of jasmonates by the F-box protein COI1. Molecular Plant, 2018, 11, 1237-1247.

  16. Shang Y, Huang SW. Multi-omics data-driven investigations of metabolic diversity of plant triterpenoids. The Plant Journal, 2018, doi:10.1111/tpj.14132.

  17. Li H, Yao R, Ma S, Hu S, Li S, Wang Y, Yan C, Xie D, Yan J. Efficient ASK-assisted system for expression and purification of plant F-box proteins. The Plant Journal, 2017, 92(4), 736-743.

  18. Zhong Y, Xue XF, Liu ZQ, Ma YS, Zeng KW, Ro DK, Bak S, Huang SW, Zhou Y. Shang Y. Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3. Molecular Plant, 2017, 10(7), 1000-1003.

  19. Liu XB, Liu YS, Huang P, Ma YS, Qing ZX, Tang Q, Cao HF, Cheng P, Zhen YJ, Zhou Y, Liu JF, Tang ZS, Zhuo YX, Zhang YC, Yu LL, Huang JL, Yang P, Peng Q, Zhang JB, Jiang WK, Zhang ZH, Lin K, Ro DK, Chen XY, Xiong XY, Shang Y, Huang SW, Zeng JG. The Genome of the Medicinal Plant Macleaya Cordata Provides New Insights into Benzylisoquinoline Alkaloid Metabolism. Molecular Plant, 2017, 10(7), 975-989.

  20. Li W, Zhang F, Wu R, Jia L, Li G, Guo Y, Liu C, Wang G. A novel N-methyltransferase in Arabidopsis appears to feed a conserved pathway for nicotinate detoxification among land plants and is associated with lignin biosynthesis. Plant Physiology, 2017, 174: 1492-1504.

  21. Zhou Y, Ma YS, Zeng JG, Duan LX, Xue XF, Wang SH, Lin T, Liu ZQ, Zeng KW, Zhong Y, Zhang S, Hu Q, Liu M, Zhang HM, Reed J, Moses T, Liu XY, Huang P, Qing ZX, Liu XB, Tu PF, Kuang HH, Zhang ZH, Osbourn A, Ro DK, Shang Y, Huang SW. Convergence and Divergence of Bitterness Biosynthesis and Regulation in Cucurbitaceae. Nature Plants, 2016, 2(12), 16183.

  22. Yan J, Li S, Gu M, Yao R, Li Y, Chen J, Yang M, Tong J, Xiao L, Nan F, Xie D. Endogenous bioactive jasmonate is composed of a set of (+)-7-iso-JA-amino acid conjugates. Plant Physiology, 2016, 172(4), 2154-2164.

  23. Li S, Chen L, Li Y, Yao R, Wang F, Yang M, Gu M, Nan F, Xie D, Yan J. Effect of GR24 stereoisomers on plant development in Arabidopsis. Molecular Plant, 2016, 10(9), 1432-1435.

  24. Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Y, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z, Lou Z, Xie D. DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 2016, 536, 469-473.

  25. Li W, Zhang F, Chang Y, Zhao T, Schranz ME, Wang G. Nicotinate O-glucosylation is an evolutionarily metabolic trait important for seed germination under stress conditions in Arabidopsis thaliana. The Plant Cell, 2015, 27: 1907-1924.

  26. Shang Y, Ma YS, Zhou Y, Zhang HM, Duan LX, Chen HM, Zeng JG, Zhou Q, Wang SH, Gu WJ, Liu M, Ren JW, Gu XF, Zhang SP, Wang Y, Yasukawa K, Bouwmeester HJ, Qi XQ, Zhang ZH, Lucas WJ, Huang SW. Biosynthesis, Regulation, and Domestication of Bitterness in Cucumber. Science, 2014, 346(6213): 1084-1088.

  27. Yan J, Li H, Li S, Yao R, Deng H, Xie Q, Xie D. The Arabidopsis F-Box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. The Plant Cell, 2013, 25: 486-498.

  28. Shang Y, Yan L, Liu ZQ, Mei C, Cao Z Xin Q, Wu FQ, Wang XF, Du SY, Jiang T, Zhang XF, Zhao R, Sun HL, Liu R, Yu YT, Zhang DP. The Mg-Chelatase H Subunit of Arabidopsis Antagonizes a Group of WRKY Transcription Repressors to Relieve ABA-Responsive Genes of Inhibition. Plant Cell, 2010, 22(6): 1909-1935.

  29. Yan J., Zhang C., Gu M., Bai Z., Zhang W., Qi T. et al. The Arabidopsis CORONATINE INSENSITIVE1 Protein Is a Jasmonate Receptor. The Plant Cell. 2009, 21: 2220-2236.

更新于2021年3月

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